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Store-operated calcium entry regulator STIMATE (STIMATE)

Target: STIMATE
Molecular classification: Other (ER-resident multi-pass membrane protein), Not a receptor, enzyme, transporter, ion channel, or classical signaling receptor

Overview

Store-operated calcium entry regulator STIMATE (STIMATE, also known as TMEM110) is an endoplasmic reticulum-resident multi-transmembrane protein that regulates store-operated calcium entry (SOCE) by maintaining and remodeling ER-plasma membrane junctions crucial for calcium signaling. It acts as a positive modulator of SOCE by physically associating with stromal interaction molecule 1 (STIM1), promoting STIM1’s conformational switch to an activated state and facilitating the interaction with ORAI1 calcium channels on the plasma membrane. Depletion of STIMATE/TMEM110 impairs STIM1 relocalization, reduces Ca²⁺ influx, and suppresses downstream activation of the calcineurin/NFAT signaling pathway. This protein is not a classic therapeutic target (e.g., receptor, enzyme, or transporter) but is important for the physiological regulation of calcium signaling complexes at the ER–plasma membrane interface

Other names: Transmembrane protein 110TMEM110Store-operated calcium entry regulator STIMATESTIM-activating enhancer encoded by TMEM110STIMATEMGC52022STIMATE-MUSTN1 (for a read-through/fusion protein)

Mechanism of action

N/A (No drugs target this molecule; mechanistically, TMEM110 (STIMATE) promotes STIM1 activation and aids the formation of Ca²⁺ influx complexes, but this is not related to known drug actions.)

Biological functions

Regulation of store-operated calcium entry (SOCE)Modulation of ER–plasma membrane junctionsPositive modulation of STIM-ORAI signaling pathwayPromotion of STIM1 activation and coupling to ORAI1 channelsRegulation of calcium/calcineurin/NFAT signaling axis

Disease associations

Other (no specific major disease associations identified; implicated in Ca²⁺ signaling pathways, which may be relevant in immunological and possibly proliferative disorders, but there is no direct or established link to major diseases such as cancer, neurodegeneration, etc.)

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