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Stratum Corneum Barrier Function
- Molecular classification
- Multi-component system, Lipid matrix, Protein matrix
01
Overview
The stratum corneum barrier function refers to the protective role of the outermost layer of the skin. This function is achieved through a complex structure of corneocytes (protein-rich cells) held together by a lipid matrix composed of ceramides, cholesterol, and free fatty acids. The barrier prevents excessive water loss, blocks entry of pathogens and toxins, maintains hydration via natural moisturizing factors (NMF), and contributes to immune defense through physical separation and antimicrobial peptides. Impairment of this function is associated with skin diseases like atopic dermatitis, psoriasis and ichthyosis.
02
Mechanism of action
N/A
03
Biological functions
Barrier functionWater retentionAntimicrobial defenseProtection from external environmentRegulation of immune response
04
Disease associations
Atopic dermatitisPsoriasisIchthyosis vulgarisEczemaAllergiesDry skin
05
Safety considerations
Compromised barrier function leading to increased susceptibility to infectionIncreased allergen penetrationExacerbation of inflammatory skin conditions
06
Biomarkers
Transepidermal water loss (TEWL)Ceramide levelsFilaggrin expressionSkin pH
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