Stratum corneum extracellular matrix

The stratum corneum extracellular matrix is a complex, non-cellular component of the outermost layer of skin, consisting mainly of lipids (such as ceramides, cholesterol, and sphingolipids), structural proteins, enzymes, and antimicrobial peptides. Its major function is to form the primary permeability barrier of the skin, protecting against dehydration and external insults. The composition and molecular organization of the extracellular matrix are critical for normal skin barrier function; defects or abnormal composition can lead to various skin diseases. The stratum corneum ECM is metabolically dynamic and undergoes structural and functional changes during the terminal differentiation of keratinocytes as they migrate outward to the skin surface[1][3]. Additional Notes: - The "stratum corneum extracellular matrix" is not a single molecule or therapeutic target (e.g., a receptor or enzyme), but rather a heterogeneous mixture of structural and functional components[1][3]. - Drugs may interact with the barrier as a whole (e.g., transdermal delivery), but no drugs specifically target this matrix as a molecular entity. - This entry may be considered incorrect as a therapeutic target, and too broad for molecular targeting as employed in pharmacology. Key facts: - Not a druggable "target" in the classical sense. - Functions by providing a barrier, not by transducing signals or catalyzing specific reactions. - No widely used or canonical abbreviation.

Other names

Stratum corneumSC extracellular matrixSC ECM