Stratum corneum hydration pathways

Stratum corneum hydration pathways" does not refer to a single molecular target, receptor, or protein but describes a collection of biological processes that regulate the hydration state of the outermost layer of the skin—the stratum corneum. These pathways involve complex interactions among lipids (such as ceramides and cholesterol), proteins (such as filaggrin and its degradation products), and humectants (notably natural moisturizing factor), all contributing to water retention and epidermal barrier function. While disruption of these pathways can influence disease states and is relevant in dermatology, there is no canonical single target with this name. Drugs and therapies addressing skin hydration do so through nonspecific support of these pathways, rather than by modulating a discrete molecule or receptor[1][2][3][4][5]. Note: "Stratum corneum hydration pathways" is not a canonical molecular target, receptor, or single protein/enzyme/transporter, and thus it does not have aliases or a standard abbreviation in molecular target databases. It is a functional concept describing physiological processes, not a discrete druggable entity.

Humectancy (attracts water), Barrier reinforcement (indirect)[3]