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Target intelligence / Profile preview
Stratum Corneum Intercellular Matrix (SCIM)
- Target
- SCIM
- Molecular classification
- Extracellular Matrix, Lipid Bilayer, Lipid Mixture, Protein Matrix
01
Overview
The stratum corneum intercellular matrix is a specialized extracellular structure found in the outermost layer of the skin, the stratum corneum. It fills the spaces between corneocytes and plays a critical role in maintaining skin barrier function and hydration. It is primarily composed of lipids (ceramides, free fatty acids, and cholesterol) arranged in multi-lamellar bilayers, along with structural proteins, enzymes, and antimicrobial peptides. Disruption or alteration of this matrix can lead to impaired barrier function seen in various dermatological conditions.
- Other names
- Intercellular Lipid MatrixStratum Corneum Lipid MatrixEpidermal Lipid Matrix
02
Mechanism of action
N/A
03
Biological functions
Barrier FunctionWater RetentionAntimicrobial DefenseMechanical ProtectionSkin Hydration
04
Disease associations
Atopic DermatitisIchthyosisXerosisEczemaPsoriasis
05
Interacting drugs
Emollients
3 more in the full profile.
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