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Target intelligence / Profile preview
Stratum Corneum Intercellular Matrix Proteins (SCIMPs)
- Target
- SCIMPs
- Molecular classification
- Structural Proteins, Enzymes, Antimicrobial Peptides
01
Overview
The stratum corneum intercellular matrix proteins are a complex mixture of structural proteins, enzymes, and antimicrobial peptides that reside within the lipid-rich extracellular space of the stratum corneum. These proteins, including loricrin, involucrin, filaggrin, and corneodesmosin, play critical roles in maintaining skin barrier function, regulating desquamation, providing mechanical strength, and contributing to innate immunity. Their dysregulation is implicated in various skin disorders.
- Other names
- Stratum Corneum ProteinsIntercellular Matrix ProteinsCornified Envelope Proteins
02
Biological functions
Barrier FunctionHydrationCell AdhesionDesquamationInnate ImmunityMechanical StrengthElasticity
03
Disease associations
IchthyosisAtopic DermatitisSkin Barrier DysfunctionInfection
04
Safety considerations
Disruption of barrier functionIncreased susceptibility to infectionInflammationAllergic reactions
05
Biomarkers
Loricrin levelsInvolucrin levelsFilaggrin levelsCorneodesmosin levelsAntimicrobial peptide levels
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