Stratum corneum keratinocyte cohesion

Stratum corneum keratin/keratinocyte cohesion refers to the **adhesive interactions between the outermost skin cells (corneocytes) within the stratum corneum**, which is the top layer of the epidermis. This cohesion is primarily mediated by specialized protein complexes called **corneodesmosomes**—modified desmosomes that link adjacent cells together. The strength and regulation of these adhesive structures are critical for maintaining an effective skin barrier, preventing water loss, and protecting against environmental insults such as pathogens and toxins[1][4]. Keratin proteins form a dense network inside these cells, contributing to their structural integrity and water-holding capacity[2][3]. The process by which living keratinocytes become non-living corneocytes involves both protein cross-linking and lipid envelope formation. Proper regulation ensures normal shedding (desquamation) at the surface; dysregulation can lead to various skin disorders characterized by either excessive scaling or compromised barrier function[1]. This entry does not refer to a specific molecular target such as a receptor or enzyme but rather describes a **cellular property/process** involving multiple proteins (keratins, desmosomal components) within the stratum corneum. Therefore, it is not considered a canonical therapeutic target on its own. If you require structured information about individual molecules involved in this process—such as "Corneodesmosin," "Desmoglein 1," or specific keratins—please specify those targets individually for more precise data extraction.

Other names

Stratum corneum cell adhesionCorneocyte cohesionKeratinocyte adhesion in stratum corneum