Stratum Corneum Lipid Matrix (SCLM)

The stratum corneum lipid matrix is a highly organized extracellular structure in the outermost layer of the skin, composed primarily of ceramides, cholesterol, and free fatty acids. It is essential for maintaining the skin's barrier function, preventing water loss, and protecting against external irritants. Deficiencies or disruptions in the lipid matrix are associated with various skin conditions like atopic dermatitis and eczema. Topical formulations containing physiological ratios of these lipids can enhance the matrix and improve skin health.

Other names

Intercellular Lipid MatrixSC Lipid MatrixEpidermal Lipid Matrix

Restoration of lipid barrier integrity, reduction of transepidermal water loss, and improved skin hydration through topical application of lipids in physiological ratios.