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Stratum Corneum Permeability Barrier (SC Barrier)
- Target
- SC Barrier
- Molecular classification
- Lipid Matrix, Cellular Structure, Physical Barrier
01
Overview
The stratum corneum permeability barrier refers to the functional and structural properties of the outermost layer of the skin, known as the stratum corneum (SC), which serves as a critical barrier between the body and its external environment. This barrier is essential for preventing excessive water loss (transepidermal water loss, TEWL) and protecting against entry of pathogens, allergens, and chemicals. It is composed of corneocytes and a lipid matrix, and its dysfunction can lead to various skin diseases.
- Other names
- Skin BarrierEpidermal Permeability BarrierCutaneous Permeability Barrier
02
Mechanism of action
Restoration of lipid matrix, increasing hydration, reducing inflammation, promoting filaggrin expression
03
Biological functions
Water retentionPrevention of pathogen entryPrevention of allergen entryPrevention of chemical entryMechanical protectionAntimicrobial defense
04
Disease associations
Atopic DermatitisXerosisEczemaInfectionsAllergic Contact DermatitisIrritant Contact Dermatitis
05
Safety considerations
Irritation from topical applicationsAllergic reactions to topical agentsExacerbation of underlying skin conditions
06
Interacting drugs
Ceramides
6 more in the full profile.
07
Biomarkers
Transepidermal Water Loss (TEWL)Skin Surface pHCeramide levelsFilaggrin expression
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