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Target intelligence / Profile preview
Stratum Corneum Protease Activity (SC Protease Activity)
- Target
- SC Protease Activity
- Molecular classification
- Enzyme, Serine Protease, Aspartate Protease, Cysteine Protease
01
Overview
Protease activity in the stratum corneum (SC) refers to the enzymatic breakdown of proteins within this outermost layer of the skin. This process is essential for normal skin desquamation (shedding of corneocytes), maintenance of barrier function, and overall skin homeostasis. Key enzymes include kallikrein-related peptidases (KLKs), tryptase, and SASPase/cathepsin D. Regulation is primarily mediated by endogenous inhibitors like LEKTI and pH-dependent activation. Dysregulation of SC protease activity is implicated in various skin conditions such as dry skin, atopic dermatitis, and psoriasis.
- Other names
- Stratum Corneum ProteolysisSC Proteolytic ActivityEpidermal Protease Activity
02
Mechanism of action
Inhibition of protease activity, enhancement of barrier function, reduction of inflammation, promotion of corneocyte shedding.
03
Biological functions
DesquamationBarrier FunctionProtein DegradationInflammation RegulationNatural Moisturizing Factor (NMF) Production
04
Disease associations
Dry Skin/XerosisAtopic DermatitisPsoriasisInflammationBarrier Dysfunction
05
Safety considerations
Excessive protease inhibition can lead to hyperkeratosisInadequate protease inhibition can exacerbate inflammatory skin conditionsPotential for irritation or allergic reactions to protease inhibitors
06
Interacting drugs
Protease inhibitors (unspecified)
3 more in the full profile.
07
Biomarkers
KLK5 activityKLK7 activityLEKTI levelsFilaggrin levelsCorneodesmosome degradation products
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