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Stratum Corneum Water Content (SC Water Content)
- Target
- SC Water Content
- Molecular classification
- Other
01
Overview
The water content of the stratum corneum (SC), the outermost layer of the epidermis, is crucial for maintaining skin barrier function, viscoelastic properties, and overall skin health. It is regulated by intercellular lipids, diffusion path length, and the natural moisturizing factor (NMF). Optimal SC hydration is essential for enzymatic activity, preventing mechanical stress, and balancing osmotic pressure. Disruptions in SC hydration are associated with dry skin conditions and impaired barrier function.
- Other names
- Skin HydrationCutaneous MoistureStratum Corneum Moisturization
02
Mechanism of action
Occlusion (reduction of transepidermal water loss); Humectancy (attracting and binding water)
03
Biological functions
Barrier functionWater retentionMaintenance of skin viscoelastic propertiesRegulation of desquamation
04
Disease associations
Dry skin conditionsAtopic dermatitisPsoriasisImpaired barrier function
05
Safety considerations
Variable effects of hydrophilic moisturizers depending on initial hydration status
06
Interacting drugs
Petrolatum
1 more in the full profile.
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