Stratum corneum water retention enhancement

The term refers to the enhancement of water retention within the stratum corneum, the skin's outermost layer, which is crucial for maintaining barrier integrity and skin health. This function depends on the interplay between intracellular proteins (notably keratin) and lipid lamellae, which together determine SC hydration and plasticity. Both natural properties and therapeutic interventions—such as topical application of glycerol and urea—increase water content by stabilizing the SC structure and binding water to keratin and lipids[1][2][3][4][6]. While not a molecular target itself, the process is a focus of dermatological research and drug development, especially for improving skin hydration and treating dryness.

Other names

Stratum corneum water retentionStratum corneum hydration enhancement

Osmolyte or humectant interaction with keratin and lipid lamellae, increasing bound water; Stabilization or extension of lamellar lipid packing to retain water[1][2][3][4][6]