Spleen function modulation via tonic effect on digestive system according to TCM theory

This concept refers to a systemic physiological principle in Traditional Chinese Medicine (TCM) rather than a single molecular target like a receptor or enzyme. In TCM, the Spleen (Pi) is considered the foundation of acquired constitution, responsible for the transformation and transportation of food into Qi and Blood (Zhu et al., 2018, Journal of Ethnopharmacology). Tonifying the Spleen involves enhancing these functions to treat Spleen Qi Deficiency, a syndrome characterized by poor appetite, fatigue, and digestive weakness. Modern research suggests this tonic effect is mediated by regulating gastrointestinal hormones like gastrin and motilin, which improve gut motility and secretion (Li et al., 2020, Frontiers in Pharmacology). It also involves the upregulation of digestive enzymes such as amylase and the modulation of the gut microbiota to improve nutrient absorption and barrier function. Bioactive compounds from TCM herbs, such as ginsenosides from Panax ginseng and atractylenolides from Atractylodes macrocephala, are known to interact with these pathways to restore metabolic balance (Wang et al., 2019, Evidence-Based Complementary and Alternative Medicine). Because this target encompasses a broad range of biological processes and multiple molecular pathways, it is classified as a therapeutic principle rather than a discrete pharmacological entity.

Other names

Spleen-tonifying effectTonifying the Spleen and QiPi-Qi-Xu therapyStrengthening the SpleenSpleen-invigorating method

Multi-target modulation of gastrointestinal motility, enhancement of digestive enzyme secretion, regulation of gut microbiota, and improvement of mitochondrial energy metabolism.