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Target intelligence / Profile preview
Streptococcal membrane protein Emm55 (Emm55)
- Target
- Emm55
- Molecular classification
- M protein family, Membrane protein
01
Overview
Emm55 is a membrane-associated M protein encoded by the emm55 gene in Streptococcus pyogenes. It functions in immune evasion and has been explored experimentally as an immunostimulatory agent in cancer models. Strains expressing Emm55 also produce DRS, which interacts with complement components.
- Other names
- M protein Emm55emm55 protein
02
Mechanism of action
Emm55 DNA vaccine induces CD4+ and CD8+ T cell infiltration into tumors, enhancing anti-tumor immunity. DRS binds complement components C6 and C7.
03
Biological functions
Immune evasionAdherenceComplement interactionImmunostimulation (experimental)
04
Disease associations
Streptococcus pyogenes infectionPharyngitisSkin infectionsInvasive diseasesRheumatic feverPost-streptococcal glomerulonephritisCancer (experimental - immunotherapy)
05
Safety considerations
Potential for autoimmune reactions due to M protein's role in rheumatic fever and glomerulonephritis.Unknown long-term effects of Emm55 DNA vaccine as immunotherapy.
06
Interacting drugs
Anti-PD-1 antibodies (experimental combination therapy)
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