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Target intelligence / Profile preview
Streptococcus pneumoniae (pneumococcus)
- Target
- pneumococcus
- Molecular classification
- Bacterium, Gram-positive bacterium, Facultative anaerobe
01
Overview
Streptococcus pneumoniae is a Gram-positive, lancet-shaped, facultative anaerobic bacterium and the primary cause of pneumococcal disease. It colonizes the human nasopharynx and can cause a range of infections, including pneumonia, meningitis, bacteremia, otitis media, and sinusitis. Virulence is primarily attributed to the polysaccharide capsule. Transmission occurs via respiratory droplets.
- Other names
- Pneumococcus
02
Mechanism of action
Antibiotic mechanisms vary (e.g., inhibition of cell wall synthesis, protein synthesis, DNA replication); Vaccines stimulate an immune response to prevent infection.
03
Biological functions
ColonizationInfectionAdherenceInvasion
04
Disease associations
PneumoniaMeningitisBacteremiaSepsisOtitis mediaSinusitisOsteomyelitisSeptic arthritisEndocarditisPeritonitisPericarditisCellulitisConjunctivitisBronchitisRhinitisBrain abscess
05
Safety considerations
Antibiotic resistanceCapsular type variationInvasive disease
06
Interacting drugs
Antibiotics
1 more in the full profile.
07
Biomarkers
C-polysaccharide antigen (urinary antigen detection)
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