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Target intelligence / Profile preview
Streptococcus pneumoniae Capsular Polysaccharide (Multiple Serotypes) (CPS)
- Target
- CPS
- Molecular classification
- Polysaccharide, Carbohydrate Polymer, Bacterial Antigen
01
Overview
The capsular polysaccharide (CPS) of *Streptococcus pneumoniae* is a high-molecular-weight, surface-exposed carbohydrate polymer that forms the outermost layer of the bacterium. It is a critical virulence factor, protecting the organism from host immune mechanisms. There are 98 recognized serotypes, each with unique chemical structures and immunological properties. The CPS is the primary target for current pneumococcal vaccines, and widespread vaccine use has altered disease epidemiology through serotype replacement.
- Other names
- Pneumococcal Capsular PolysaccharideS. pneumoniae CPSCapsular PolysaccharidePneumococcal Capsule
02
Mechanism of action
Antibodies generated against CPS promote opsonization and phagocytosis of Streptococcus pneumoniae.
03
Biological functions
Immune evasionPhagocytosis inhibitionComplement inhibitionVirulence factorCapsule formation
04
Disease associations
InfectionPneumoniaMeningitisBacteremiaOtitis Media
05
Safety considerations
Serotype replacement following vaccinationLimited protection against non-vaccine serotypes
06
Interacting drugs
PPV23 (Pneumovax23®)
1 more in the full profile.
07
Biomarkers
Serotype prevalence in diseaseAntibody titers against specific serotypes
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