Streptococcus pneumoniae capsular polysaccharide antigens (10 serotypes) (PCV10 antigens)

Streptococcus pneumoniae capsular polysaccharide antigens are complex carbohydrate polymers that encapsulate the bacterium, serving as its primary virulence factor by inhibiting phagocytosis [4]. The 10-serotype variant specifically refers to the antigens from serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F, which are common causes of invasive disease globally [1]. These antigens are used in conjugate vaccines, where they are chemically linked to a carrier protein (such as Protein D from non-typeable Haemophilus influenzae) to enhance immunogenicity, particularly in infants [2]. Upon administration, the immune system recognizes these polysaccharides and generates serotype-specific antibodies that facilitate bacterial clearance via opsonophagocytosis [3]. This targeted approach effectively prevents life-threatening infections including pneumonia, meningitis, and febrile bacteremia [1].

Other names

Pneumococcal capsular polysaccharidesS. pneumoniae CPS10-valent pneumococcal conjugate vaccine antigens

Induction of active immunity through the production of serotype-specific opsonizing antibodies and memory B-cells.