Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Streptococcus pneumoniae Capsular Polysaccharide-CRM197 Conjugate (Pn CPS-CRM197 Conjugate)
- Target
- Pn CPS-CRM197 Conjugate
- Molecular classification
- Polysaccharide-protein conjugate, Vaccine
01
Overview
A vaccine composed of Streptococcus pneumoniae capsular polysaccharides covalently linked to CRM197 carrier protein. This conjugate elicits a T cell-dependent immune response, leading to robust antibody production, immunological memory, and protection against pneumococcal disease.
- Other names
- Pneumococcal conjugate vaccinePCVPrevnarSynflorix
02
Mechanism of action
Induction of T cell-dependent antibody response against Streptococcus pneumoniae capsular polysaccharides via B cell presentation of CRM197-derived peptides to T helper cells, leading to B cell activation, class switching, affinity maturation, and memory cell formation.
03
Biological functions
Immune response inductionAntibody productionB cell activationT cell activationImmunological memory formation
04
Disease associations
InfectionPneumococcal diseasePneumoniaMeningitisBacteremia
05
Safety considerations
Injection site reactionsFeverAllergic reactions (rare)Guillain-Barré syndrome (very rare)
06
Biomarkers
Anti-capsular polysaccharide IgG antibody titersB cell memory responseOpsonophagocytic activity (OPA)
Beyond the preview
Go deeper on Streptococcus pneumoniae Capsular Polysaccharide-CRM197 Conjugate (Pn CPS-CRM197 Conjugate).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Streptococcus pneumoniae Capsular Polysaccharide-CRM197 Conjugate (Pn CPS-CRM197 Conjugate).