Streptococcus pneumoniae capsular polysaccharide serotype 10A (CPS10A)

Streptococcus pneumoniae capsular polysaccharide serotype 10A is a complex surface carbohydrate that serves as a critical virulence factor, shielding the bacterium from host immune recognition and phagocytic clearance. It is composed of repeating oligosaccharide units containing galactose, ribitol-5-phosphate, and glucose, which define its unique antigenic signature. Serotype 10A has been identified as a significant cause of invasive pneumococcal disease, including pneumonia, meningitis, and bacteremia, especially as a 'replacement serotype' following the widespread use of earlier lower-valency conjugate vaccines. To combat this, the polysaccharide is used as a therapeutic target and active component in advanced vaccines like the 20-valent pneumococcal conjugate vaccine (PCV20) and the 23-valent polysaccharide vaccine (PPSV23). These vaccines stimulate the immune system to produce high-affinity, serotype-specific IgG antibodies that facilitate bacterial opsonization and killing by host immune cells.

Other names

Pneumococcal capsular polysaccharide serotype 10AStreptococcus pneumoniae CPS10APn10A polysaccharidePneumococcal polysaccharide 10AS. pneumoniae serotype 10A antigen

Active immunization inducing a T-cell dependent (for conjugate vaccines) or T-cell independent (for polysaccharide vaccines) immune response resulting in the production of serotype-specific opsonizing antibodies.