Streptococcus pneumoniae capsular polysaccharide serotype 23B (Spn23B CPS)

Streptococcus pneumoniae capsular polysaccharide serotype 23B is a complex carbohydrate polymer that constitutes the outermost protective layer of the 23B serotype of the pneumococcus bacterium. This polysaccharide is a critical virulence factor that enables the pathogen to evade the host immune system by preventing opsonophagocytosis by leukocytes (Source: PubMed, PMID: 31510102). Serotype 23B has gained clinical prominence as a leading cause of invasive pneumococcal disease (IPD) and antibiotic resistance in the era following the introduction of earlier-generation conjugate vaccines that did not cover this specific serotype (Source: CDC, Pink Book). In pharmaceutical development, this polysaccharide is utilized as a purified antigen in next-generation pneumococcal conjugate vaccines (PCVs), such as the 21-valent vaccine Capvaxive. When conjugated to a carrier protein like CRM197, the polysaccharide induces a T-cell dependent immune response, resulting in the production of high-affinity antibodies and the establishment of immunological memory (Source: FDA, Capvaxive Prescribing Information). These vaccine-induced antibodies bind to the 23B capsule, allowing for complement activation and subsequent destruction of the bacteria, thereby protecting against pneumonia, meningitis, and sepsis.

Other names

Pneumococcal polysaccharide serotype 23BCPS23BSerotype 23B capsular antigenStreptococcus pneumoniae serotype 23B capsular polysaccharide

Active immunization via induction of serotype-specific opsonophagocytic antibodies that facilitate bacterial clearance.