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Target intelligence / Profile preview
Streptococcus pneumoniae Polysaccharide Antigens (CPS)
- Target
- CPS
- Molecular classification
- Capsular Polysaccharide, Cell Wall Polysaccharide, Bacterial Antigen, Teichoic acid
01
Overview
Streptococcus pneumoniae polysaccharide antigens are complex carbohydrates on the bacterial surface, primarily capsular polysaccharides (CPS), that act as virulence factors by inhibiting phagocytosis. Over 90 serotypes exist, each with a unique CPS structure. These antigens are key targets for vaccines like PPSV23 (purified polysaccharides) and PCV13 (conjugated polysaccharides), which induce protective antibody responses and reduce pneumococcal disease incidence.
- Other names
- Pneumococcal Capsular PolysaccharidesC-PolysaccharideS. pneumoniae CPSPneumococcal polysaccharide
02
Mechanism of action
Induction of opsonizing antibodies; T-cell dependent B cell activation (PCV13)
03
Biological functions
Immune evasionInhibition of phagocytosisVirulenceB cell activation
04
Disease associations
PneumoniaMeningitisBacteremiaOtitis MediaSinusitisInfection
05
Safety considerations
Limited efficacy in young children (PPSV23)Serotype replacementImmunogenicity in immunocompromised individualsInjection site reactions
06
Interacting drugs
PPSV23 (Pneumovax 23)
1 more in the full profile.
07
Biomarkers
Anti-pneumococcal IgG antibody titersSerotype-specific antibody levels
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