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Target intelligence / Profile preview
Streptococcus pneumoniae serotype 1 capsular polysaccharide (CPS type 1)
- Target
- CPS type 1
- Molecular classification
- Polysaccharide, Capsular polysaccharide
01
Overview
The Streptococcus pneumoniae serotype 1 capsular polysaccharide (CPS) is a key surface structure and major virulence factor that shields the bacterium from host phagocytosis and opsonophagocytic clearance. It is synthesized via a Wzx/Wzy-dependent pathway involving lipid-linked repeat units translocated across the membrane, polymerized, and covalently linked at the reducing end (often glucose) to peptidoglycan GlcNAc via a 1,6 glycosidic bond. Serotype 1 CPS initiation uniquely involves a teichoic acid biosynthesis glycosyltransferase. With 98 distinct serotypes recognized, protection by vaccines is strictly serotype-specific, targeting CPS to elicit protective antibodies. Genes in the cps1 locus (wzg to ugd) are highly conserved and can transfer to commensal streptococci like S. mitis.
- Other names
- serotype 1 CPSpneumococcal serotype 1 capsuletype 1 capsular polysaccharide
02
Mechanism of action
Induces serotype-specific antibodies for opsonophagocytic killing
03
Biological functions
Virulence factorProtection from opsonophagocytic clearanceAdhesionBiofilm formationResistance to complement-mediated lysisNasopharyngeal colonization
04
Disease associations
Infection
05
Interacting drugs
Pneumococcal polysaccharide vaccines (serotype-specific conjugates)
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