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Streptococcus pneumoniae serotype 19A capsular polysaccharide
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
The capsular polysaccharide of Streptococcus pneumoniae serotype 19A is a complex carbohydrate structure that forms the outer capsule of the bacterium. It is a key virulence factor, protecting the bacterium from phagocytosis and enabling it to cause invasive diseases. It consists of repeating trisaccharide units of rhamnose, N-acetyl-mannosamine, and glucose. Serotype 19A has become a prevalent cause of IPD, especially after the introduction of vaccines targeting other serotypes. Purified capsular polysaccharide is used as an antigenic component in pneumococcal vaccines.
02
Mechanism of action
Antibody-mediated opsonization and complement activation, leading to phagocytosis and clearance of Streptococcus pneumoniae serotype 19A.
03
Biological functions
Anti-phagocytic shieldImmune evasionVirulence factor
04
Disease associations
InfectionPneumoniaMeningitisBacteremiaInvasive Pneumococcal Disease (IPD)
05
Safety considerations
Potential for serotype replacementAntimicrobial resistance of serotype 19A strains
06
Interacting drugs
Pneumovax 23
2 more in the full profile.
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