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Target intelligence / Profile preview
Streptococcus pneumoniae serotype 5 capsular polysaccharide (null)
- Target
- null
- Molecular classification
- Polysaccharide, Capsular polysaccharide, Other
01
Overview
The Streptococcus pneumoniae serotype 5 capsular polysaccharide (CPS) is a surface polysaccharide that forms a protective capsule essential for bacterial virulence, enabling nasopharyngeal colonization, evasion of host phagocytosis, adhesion, biofilm formation, and resistance to complement-mediated killing. It is synthesized via the Wzy-dependent pathway, with repeat units assembled on lipid carriers, translocated across the membrane, polymerized, and covalently linked via a direct 1,6-glycosidic bond from the reducing-end glucose to GlcNAc in peptidoglycan. This CPS is a key vaccine antigen in formulations like PCV13, targeting serotype-specific immunity to prevent pneumococcal diseases such as pneumonia and sepsis.
- Other names
- serotype 5 CPSS. pneumoniae serotype 5 CPS
02
Mechanism of action
Antibody induction against CPS for opsonophagocytosis and bacterial clearance
03
Biological functions
Virulence factorProtection from phagocytosisAdhesionBiofilm formationResistance to opsonophagocytosis
04
Disease associations
Infection
05
Interacting drugs
Pneumococcal conjugate vaccines (PCV13 includes serotype 5 CPS as antigen)
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