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Target intelligence / Profile preview
Streptococcus pneumoniae serotype 6A Capsular Polysaccharide (CPS 6A)
- Target
- CPS 6A
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
Streptococcus pneumoniae serotype 6A capsular polysaccharide (CPS 6A) is a complex carbohydrate polymer that forms the outer capsule of S. pneumoniae serotype 6A. It is a major virulence factor, protecting the bacterium from phagocytosis and complement-mediated killing. CPS 6A is a key target for pneumococcal conjugate vaccines such as PCV13 and PCV21, which induce antibodies that promote opsonization and clearance of the bacteria. The unique structure of CPS 6A, determined by its cps locus, distinguishes it antigenically and is crucial for vaccine efficacy.
- Other names
- S. pneumoniae 6A Capsular PolysaccharideSerotype 6A Capsular PolysaccharidePneumococcal serotype 6A capsule6A CPS
02
Mechanism of action
Antibody-mediated opsonization and phagocytosis following vaccination.
03
Biological functions
Capsule FormationImmune EvasionAdhesionVirulence
04
Disease associations
PneumoniaMeningitisSepsisOtitis MediaInvasive Pneumococcal Disease
05
Interacting drugs
PCV13
2 more in the full profile.
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