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Target intelligence / Profile preview
Streptococcus pneumoniae type 19f capsular polysaccharide antigen-specific B cell receptor (19F CPS-specific BCR)
- Target
- 19F CPS-specific BCR
- Molecular classification
- Receptor, B cell receptor, Membrane-bound Immunoglobulin
01
Overview
The B cell receptor (BCR) specific for the capsular polysaccharide antigen of Streptococcus pneumoniae serotype 19F. This BCR, expressed on B cells, mediates the specific immune recognition of this bacterial capsule, leading to B cell activation and antibody production. The type 19F capsular polysaccharide is a T-independent type II antigen. Higher concentrations of anticapsular antibodies are required for effective opsonization due to the capsule's resistance to complement-mediated clearance. PD-1 signaling can suppress the function of these B cells.
- Other names
- Anti-Streptococcus pneumoniae 19F capsular polysaccharide BCRType 19F CPS-specific B cell receptorBCR specific for S. pneumoniae serotype 19F capsular polysaccharide
02
Mechanism of action
The BCR binds to the type 19F capsular polysaccharide, leading to B cell activation, proliferation, and differentiation into antibody-secreting plasma cells. In the context of vaccines, this induces protective antibody responses.
03
Biological functions
Antigen recognitionB cell activationAntibody productionImmune response to Streptococcus pneumoniae
04
Disease associations
InfectionPneumococcal diseaseImmunity to Streptococcus pneumoniae serotype 19F
05
Safety considerations
Potential for vaccine failure in immunocompromised individualsSerotype replacement after vaccinationLimited efficacy of polysaccharide vaccines in young children (improved with conjugation)
06
Interacting drugs
Pneumococcal polysaccharide vaccine (PPSV)
2 more in the full profile.
07
Biomarkers
Anti-19F capsular polysaccharide antibody titerNumber of 19F-specific B cellsPD-1 expression on 19F-specific B cells
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