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Streptococcus pneumoniae type 2 capsular polysaccharide

Molecular classification: Polysaccharide, Capsular Polysaccharide

Overview

The Streptococcus pneumoniae type 2 capsular polysaccharide (CPS) is a high-molecular-weight carbohydrate polymer that forms the outermost layer of the bacterium S. pneumoniae serotype 2. This capsule is essential for bacterial virulence, serving as a protective barrier against host immune responses, particularly by interfering with opsonophagocytic clearance mechanisms. The CPS is also the primary target for current pneumococcal vaccines, and its structure determines serotype specificity.

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Immune evasionAntigen presentation

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Serotype-specific immunity limits broad protection

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