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Target intelligence / Profile preview
Streptococcus pneumoniae Type 4 Capsular Polysaccharide (CPS Type 4)
- Target
- CPS Type 4
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The capsular polysaccharide (CPS) of Streptococcus pneumoniae serotype 4 is a major virulence factor that protects the bacterium from host immune responses. It consists of repeating oligosaccharide units and is a key target for pneumococcal vaccines. Protection is serotype-specific, making multivalent vaccines necessary to cover the diversity of circulating serotypes.
- Other names
- S. pneumoniae Type 4 CPSPneumococcal Capsular Polysaccharide Type 4Type 4 Capsular PolysaccharideS. pneumoniae serotype 4 capsule
02
Mechanism of action
Antibody-mediated opsonization and phagocytosis after vaccination.
03
Biological functions
Immune evasionVirulenceAntigen presentationOpsonophagocytosis inhibition
04
Disease associations
PneumoniaMeningitisBacteremiaOtitis mediaStreptococcus pneumoniae infection
05
Safety considerations
Serotype-specific protection onlyVaccine efficacy limited by serotype diversityPotential for serotype replacement following vaccination
06
Interacting drugs
Pneumococcal vaccines (multivalent)
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