Streptococcus pneumoniae type 6B capsular polysaccharide (Type 6B CPS)

The Streptococcus pneumoniae type 6B capsular polysaccharide is a serotype-specific carbohydrate polymer that forms the outermost layer of the bacterium. This capsule is covalently attached to the cell wall peptidoglycan and serves as a dominant surface structure and a critical virulence factor, primarily by protecting the bacterium from phagocytosis by host immune cells. The capsular polysaccharide is highly immunogenic and forms the basis for serotype-specific immunity and is the primary target of current pneumococcal vaccines. The purified type 6B capsular polysaccharide has been used as an antigenic component in both plain-polysaccharide and protein-conjugate pneumococcal vaccines, like Prevnar13.

Other names

Streptococcus pneumoniae Type 6B Polysaccharide Conjugate AntigenS. pneumoniae Polysaccharide–CRM197 Conjugate Serotype 6BPREVNAR13 Component Streptococcus pneumoniae Type 6B Capsular Polysaccharide Diphtheria CRM197 Protein Conjugate Antigen

Antibody generation via B-cell activation