Striatin, calmodulin-binding protein pseudogene

This entry represents a pseudogene annotated as related to striatin, a neuronal calmodulin-binding protein. Pseudogenes are genomic elements resembling functional genes but are rendered non-coding and inactive, typically due to frame shifts, truncations, or other inactivating mutations. While the protein-coding STRN gene (striatin) encodes a calmodulin-binding scaffolding protein involved in multiple signaling pathways, the striatin, calmodulin binding protein pseudogene is considered non-coding and lacks evidence for protein translation or direct therapeutic relevance. Pseudogenes were traditionally viewed as "junk DNA," but recent studies suggest some may have RNA-level regulatory effects; there is no evidence that this particular pseudogene has such a role. It is not considered a therapeutic target and should generally be excluded from druggable genome or actionable gene sets. The entity ENSG00000275490 is a pseudogene related to striatin and does not encode a functional receptor, enzyme, transporter, or other actionable protein target. It is not used in therapy, biomarker panels, and has no associated drugs or therapeutic mechanism. There is nothing to suggest that its sequence or annotation is incorrect, but it is not suitable for use as a canonical drug target for therapeutic or biomarker purposes.

Other names

striatin pseudogenecalmodulin-binding protein pseudogeneSTRN pseudogene