Striatin-interacting protein 2 (STRIP2)

Striatin-interacting protein 2 (STRIP2) is a cytosolic scaffolding protein and a core component of the striatin-interacting phosphatase and kinase (STRIPAK) complex, essential for cytoskeleton organization, cell migration, and cell morphology regulation. It plays a central role in cell signaling, notably modulating cardiac calcium handling by directly interacting with the L-type calcium channel in cardiomyocytes—a function crucial for heartbeat efficiency. STRIP2 is implicated in cancer progression, particularly promoting tumor cell proliferation, migration, and invasion in lung adenocarcinoma, likely via regulation of the Akt/mTOR pathway and changes in EMT markers. STRIP2 additionally influences embryonic stem cell differentiation through epigenetic mechanisms linking it to histone modifications. Dysregulation or loss of STRIP2 function is associated with adverse disease outcomes in both cancer and cardiac contexts, underscoring its significance as a potential therapeutic target and disease biomarker[1][2][3][4][5].

Other names

FAM40BFAR11BMyoscapeKIAA1170Protein FAM40BFAR11 factor arrest 11 homolog Bfamily with sequence similarity 40 member Bhomolog of yeast FAR11 protein 2

Regulation of cellular signaling pathways such as Akt/mTOR - Modulation of epithelial-mesenchymal transition (EMT) markers - Regulates cell proliferation and migration via STRIPAK complex