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Target intelligence / Profile preview
Stromal Cell-Derived Factor 1 Alpha (SDF-1α)
- Target
- SDF-1α
- Molecular classification
- Chemokine, CXC chemokine
01
Overview
Stromal cell-derived factor 1 alpha (SDF-1α), also known as CXCL12-alpha, is a CXC chemokine that plays a crucial role in various biological processes, including immune cell trafficking, stem cell homing, tissue repair, and development. It primarily signals through the CXCR4 and CXCR7 receptors, activating downstream pathways like PI3K/Akt and MAPK/ERK. Its involvement in cancer progression, cardiovascular repair, and nervous system development makes it a target of interest for therapeutic interventions.
- Other names
- CXCL12-alphaC-X-C motif chemokine 12 alphaCXCL12aSDF1A
02
Mechanism of action
CXCR4 and CXCR7 receptor modulation, PI3K/Akt pathway activation, MAPK/ERK pathway activation
03
Biological functions
Immune cell traffickingStem cell homingTissue repairHematopoiesisAngiogenesisNeuronal migrationCell proliferationCell survivalChemotaxis
04
Disease associations
CancerMyocardial infarctionNeurodevelopmental disordersNeuroinflammatory diseasesCoronary artery diseaseTumorigenesis
05
Safety considerations
Potential for promoting tumor growth and metastasisComplex signaling pathways with context-dependent effects
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