Stromal cell-derived factor 2 (SDF2)

Stromal cell-derived factor 2 (SDF2) is a conserved, ubiquitously expressed protein localized mainly in the endoplasmic reticulum (ER), where it functions as a regulatory cofactor involved in protein folding and the unfolded protein response (UPR)[1][2][3][4][5]. Unlike SDF1/CXCL12 and other stromal cell-derived factors, SDF2 is not a chemokine or receptor, but rather an ER-resident protein associated with protein folding and cellular stress adaptation[1][2][4]. SDF2 expression is altered in cancer, placental disorders, and other disease contexts linked to ER stress, making it a candidate biomarker for certain conditions but not a direct druggable target[2][4][5]. Critical notes: - SDF2 should not be confused with "SDF-1" (CXCL12), a chemokine/receptor widely targeted in drug discovery. - The name "stromal cell derived factor 2" is correct for this protein; however, its function is regulatory in ER homeostasis, *not as a receptor or chemokine*. - SDF2's therapeutic and biomarker potential is still being explored, especially for ER stress-related pathologies[1][2].

Other names

SDF2Stromal cell derived factor 2Stromal cell-derived factor 2SDF-2