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Target intelligence / Profile preview
Stromal interaction molecule 1 (STIM1)
- Target
- STIM1
- Molecular classification
- Transmembrane protein, Calcium sensor, ER resident protein
01
Overview
Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane protein residing primarily in the endoplasmic reticulum (ER) membrane. It functions as a crucial calcium sensor, detecting decreases in ER calcium concentration and activating store-operated calcium entry (SOCE) by interacting with ORAI channels at the plasma membrane. This process replenishes intracellular calcium stores and triggers downstream signaling pathways involved in gene expression, cell growth, immune responses, and muscle function. Dysregulation of STIM1 is associated with immunodeficiency, myopathies, and cardiac hypertrophy.
02
Mechanism of action
Modulation of STIM1 activity to control SOCE
03
Biological functions
Calcium homeostasisStore-operated calcium entry (SOCE)Calcium signalingER stress responseMuscle contraction/relaxationImmune response
04
Disease associations
ImmunodeficiencyTubular aggregate myopathyStormorken syndromeCardiac hypertrophy
05
Safety considerations
Potential for dysregulation of calcium homeostasis leading to various cellular dysfunctions.Off-target effects due to broad expression and involvement in multiple signaling pathways.
06
Biomarkers
STIM1 expression levels in tissue samplesSTIM1 serum/plasma levels
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