Stromal vascular fraction cells (SVF)

Stromal vascular fraction (SVF) cells are a heterogeneous collection of non-adipocyte cells obtained from adipose tissue through enzymatic digestion or mechanical dissociation (Source: PubMed 27014503). This population includes adipose-derived stem cells (ADSCs), endothelial progenitor cells, pericytes, fibroblasts, and various immune cells such as macrophages and lymphocytes (Source: PubMed 30631533). SVF is not a single molecular target like a receptor or enzyme; rather, it is a therapeutic cellular product used in regenerative medicine (Source: PubMed 31133587). Its biological function involves the secretion of pro-angiogenic and anti-inflammatory factors, which facilitate tissue repair and modulate the immune response (Source: PubMed 28210533). Clinically, SVF is applied in treating conditions such as osteoarthritis, chronic wounds, and ischemic diseases, where it promotes healing through paracrine mechanisms and potential differentiation (Source: NIH/StatPearls). Despite its therapeutic potential, SVF faces challenges regarding the lack of standardized isolation protocols and the inherent variability of cell composition between donors (Source: PubMed 30631533).

Other names

Adipose-derived stromal vascular fractionAdipose SVFNon-adipocyte cell fractionAdipose tissue-derived stromal vascular fraction

Paracrine signaling, immunomodulation, and cellular differentiation (Source: PubMed 31133587).