Target intelligence / Profile preview

Strontium ion release (null)

Target
null
Molecular classification
Other
01

Overview

Strontium ion release is the process by which Sr²⁺ ions are liberated from materials (such as bone cements, hydrogels, or mineral scaffolds) or environments into surrounding fluids or tissues[2][4][6]. Biologically, strontium can substitute for calcium in several physiological processes, including the triggering of neurotransmitter release at synapses and influencing muscle contraction[1][3][5]. In biomedical applications, the controlled release of strontium ions from materials has been explored for its beneficial effects on bone regeneration, as strontium promotes osteoblastic activity and inhibits osteoclastic bone resorption, and has also been studied for cardiovascular protection in animal models[2][4]. However, "strontium ion release" does not refer to a discrete molecule, protein, or receptor, but rather to a physicochemical and biological phenomenon. Because "strontium ion release" is not a canonical molecular target, most fields above are not applicable or return null, and the entry is best classified as "incorrect" if used as a molecular target in a drug discovery context.

Other names
Strontium releaseSr²⁺ releaseStrontium ion elution
02

Mechanism of action

Release of Sr²⁺ ions may substitute for Ca²⁺ in activating biological processes: e.g., strontium can trigger neurotransmitter release at synapses by entering through calcium channels Released Sr²⁺ influences osteoblast and osteoclast function in bone biology

03

Biological functions

Modulation of neurotransmitter releaseSignal transduction (secondary to ion substitution)Stimulation of angiogenesisOsteogenesis/osteoblast proliferationRegulation of muscle contraction (when substituting for Ca²⁺)
04

Disease associations

Osteoporosis (via therapeutic bone cements or implants)Ischemic heart disease (with myocardial protection, in experimental settings)Other (as a modulatory agent, not a disease-causing or direct therapeutic target)
05

Safety considerations

Systemic strontium exposure at high levels may have toxicity risks, including cardiovascular concern in some contextsExcessive ion release from implants can cause local or systemic adverse effects

Beyond the preview

Go deeper on Strontium ion release (null).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Full profile access

Explore the programs pursuing this target and their development progress.

  • Drug candidates
  • Developers
  • Development stage

Clinical trials

Full profile access

Follow the clinical studies evaluating therapies directed at this target.

  • Trial design
  • Status
  • Readouts

Competitive landscape

Full profile access

Compare approaches across drug candidates, modalities, and indications.

  • Programs
  • Modalities
  • Indications

Literature & evidence

Full profile access

Investigate the research and source evidence behind target biology and development.

  • Publications
  • Sources
  • Analysis

Patents

Full profile access

Explore patent activity around therapies and technologies addressing this target.

  • Patents
  • Assignees
  • Technologies

Research & analysis

Full profile access

Connect target biology, drug development, and emerging evidence in your research.

  • Biology
  • Development news
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on Strontium ion release (null).

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call