Structural maintenance of chromosomes 5 pseudogene

Structural maintenance of chromosomes 5 pseudogene (also known as LOC100421160, ENSG00000255437, or AC023538.1) is a non-protein-coding pseudogene related to the structural maintenance of chromosomes 5 (SMC5) gene in humans[4][7][5]. Unlike true protein-coding genes, pseudogenes like this do not encode a functional protein[8]. While SMC5 has roles in chromatin structure, DNA repair, and genome stability, the pseudogene itself lacks known direct biological roles or therapeutic targeting relevance. However, some pseudogenes can regulate their protein-coding counterparts at the RNA level or via small RNAs; such regulatory functions are possible but not specifically demonstrated for this pseudogene[8]. There are no known drugs, mechanisms, or disease roles clinically associated with this pseudogene, and it is not regarded as a druggable or therapeutic target. This entry refers to a pseudogene and not a protein-coding therapeutic target. If your interest is in SMC5 protein (which is a genuine component of the SMC complex with biological and possible disease relevance), then SMC5 is the canonical protein, but ENSG00000255437 (LOC100421160) itself does not encode a functional protein and is not a validated therapeutic target[4][7][8].

Other names

LOC100421160ENSG00000255437AC023538.1