Structural maintenance of chromosomes protein 3 (SMC3)

Structural maintenance of chromosomes protein 3 (SMC3) is a core subunit of the cohesin complex, essential for sister chromatid cohesion, chromosome segregation, and DNA repair during the cell cycle[1][2][4]. SMC3 partners with SMC1A to form a heterodimer and, with additional components, creates a ring-like complex tethering chromatin fibers. Its post-translational modifications (including acetylation and phosphorylation) modulate its functions and ensure proper chromosomal behavior. In certain cell types, SMC3 is secreted as the proteoglycan bamacan, contributing to basement membrane integrity. Mutations or dysregulation of SMC3 are implicated in Cornelia de Lange syndrome and several cancers due to their impact on chromosomal stability, cell proliferation, and tissue development[1][2][3][4].

Other names

SMC3BAMBMHCSPG6SMC3L1HCAPCDLS3BamacianBasement membrane-associated chondroitin proteoglycanChondroitin sulfate proteoglycan 6Chromosome-associated polypeptide

HDAC8 inhibitors block deacetylation of SMC3, impacting cell cycle progression. In cancer, overexpression or mutation of SMC3 may affect chromosomal stability, with potential for targeted therapies in research (no approved direct agents).