Structure-specific endonuclease subunit SLX1 homolog B (SLX1B)

Structure-specific endonuclease subunit SLX1 homolog B (SLX1B) is the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease complex involved in resolving DNA secondary structures that arise during DNA repair and recombination.[1][2][3][8] SLX1B is critical in maintaining genome stability by introducing single-strand cuts at DNA junctions, such as 5'-flap structures and Holliday junctions, to facilitate repair.[1][8] It possesses GIY-YIG endonuclease activity and is primarily localized to the nucleus.[4][8] The gene has been implicated in regulation of genome stability, with some reported links to autism spectrum disorder in genetic studies, but is not recognized as a classical therapeutic target like receptors or kinases.[1][10]

Other names

SLX1 homolog B, structure-specific endonuclease subunitGIYD2GIYD1SLX1MGC5178GIY-YIG domain-containing protein 1SLX1 structure-specific endonuclease subunit homolog B