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Target intelligence / Profile preview
Structure-specific endonuclease subunit SLX1A (SLX1A)
- Target
- SLX1A
- Molecular classification
- Enzyme, Structure-specific endonuclease
01
Overview
Structure-specific endonuclease subunit SLX1A (SLX1A) is the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease complex, which plays a pivotal role in the resolution of branched DNA structures formed during DNA repair and homologous recombination. SLX1A is specifically active against DNA substrates such as 5'-flap structures and Holliday junctions, facilitating the generation of ligatable DNA duplexes during the repair process. It is essential for maintaining genome stability by preventing the persistence of harmful DNA intermediates; defects in this protein are associated with several human diseases, notably those linked to defective DNA repair and genome maintenance, including various cancers and Fanconi anemia[1][2][8][9][11].
- Other names
- Structure-specific endonuclease subunit SLX1GIY-YIG domain-containing protein 1GIYD1SLX1GIYD2SLX1 homolog A
02
Biological functions
DNA repairDNA recombinationGenome stability
03
Disease associations
CancerFanconi anemiaUrinary bladder carcinomaIsolated asymptomatic elevation of creatine phosphokinasePlasma fibronectin deficiencyFRAXF syndromePentosuriaMetabolic myopathy due to lactate transporter defectMyopathy due to calsequestrin and SERCA1 protein overload
04
Safety considerations
Potential genome instability if inhibited or lost, possibly impacting DNA repair fidelity and leading to DNA damage-related pathologies[9].
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