STX16-NPEPL1 readthrough (STX16-NPEPL1)

STX16-NPEPL1 readthrough is a naturally occurring non-coding RNA transcript that spans the region between the syntaxin 16 (STX16) and aminopeptidase-like 1 (NPEPL1) genes on chromosome 20[2][3][5]. It is a product of readthrough transcription—meaning that RNA polymerase continues transcription from one gene into the neighboring gene without terminating as usual. This readthrough RNA is annotated as a candidate for nonsense-mediated mRNA decay (NMD), suggesting it may be rapidly degraded and unlikely to generate a functional protein[2][5]. There is no evidence to classify it as a conventional therapeutic target (receptor, enzyme, transporter, etc.), nor does it have established direct associations as a biomarker or a pathological agent. However, deletions encompassing STX16 and NPEPL1 regions are associated with rare genetic diseases, suggesting the locus may have clinical relevance indirectly through other mechanisms[1][5].

Other names

STX16-NPEPL1 readthrough (NMD candidate)STX16-NPEPL1 (HGNC:41993, NCBI Gene:100534593, Ensembl:ENSG00000254995)

None applicable; there are no drugs targeting this transcript[5].