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Target intelligence / Profile preview
STX17 antisense RNA 1 (STX17-AS1)
- Target
- STX17-AS1
- Molecular classification
- Long non-coding RNA, Other
01
Overview
STX17 antisense RNA 1 (STX17-AS1), also referenced as LOC441461, is a long non-coding RNA transcribed antisense to the STX17 gene. It functions as an oncogenic lncRNA in colorectal cancer, modulating cancer cell growth, motility, and cell cycle progression primarily through the RhoA/ROCK signaling pathway. Knockdown of STX17-AS1 reduces proliferation, induces apoptosis, and impairs cell migration, indicating its role in tumor progression. It has been proposed as a biomarker and as a possible entry point for understanding lncRNA-mediated oncogenesis, but it is not a direct therapeutic target in the sense of classical protein targets[3][2][1].
- Other names
- STX17-AS1STX17 antisense RNA 1STX17-DTLOC101928438STX17 divergent transcriptNAMA
02
Mechanism of action
Not classically druggable; modulates cell signaling (notably via RhoA/ROCK pathway) by acting as a molecular regulator
03
Biological functions
Regulation of cell proliferationModulation of cell motility/migrationCell cycle regulationApoptosis
04
Disease associations
Cancercolorectal cancer
05
Biomarkers
Potential biomarker for colorectal cancer cell proliferation and metastasis
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