Target intelligence / Profile preview

Substance P (SP)

Target: SP
Molecular classification: Neuropeptide, Tachykinin

Overview

Substance P is an 11-amino acid neuropeptide that belongs to the tachykinin family. It is widely expressed in the central nervous system (CNS), peripheral nervous system, and immune cells. SP plays a key role in various physiological and pathological processes, particularly those involving pain transmission, inflammation, and stress responses. Its main receptor is the neurokinin 1 receptor (NK1R).

Other names: Neurokinin P

Mechanism of action

N/A - Substance P itself is not a drug, but a target for drug development

Biological functions

NeurotransmissionNeuromodulationPain transmission (nociception)InflammationImmune cell migrationCytokine productionVasodilationBronchoconstrictionSmooth muscle contractionStress response

Disease associations

PainInflammationMajor Depressive DisorderAnxiety DisordersCancer

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