Succinate dehydrogenase complex flavoprotein subunit A (SDHA)

Succinate dehydrogenase complex flavoprotein subunit A (SDHA) is the major catalytic subunit of succinate-ubiquinone oxidoreductase (complex II of the mitochondrial respiratory chain). SDHA catalyzes the oxidation of succinate to fumarate in the citric acid (Krebs) cycle and transfers electrons to the electron transport chain, playing a crucial role in cellular energy metabolism. SDHA also participates in cell signaling as a tumor suppressor and as a regulator of the hypoxia-inducible factor (HIF) pathway by controlling succinate levels. Germline or somatic mutations in SDHA are associated with several cancers, most notably SDH-deficient gastrointestinal stromal tumors and paragangliomas, as well as metabolic and neurodegenerative disorders such as Leigh syndrome[1][2][3][4].

Other names

SDHAFlavoprotein subunit of complex IIFPSDH1SDH2SDHFSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialSuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)CMD1GGMC2DN1PGL5PPGL5NDAXOAMalate dehydrogenase [quinone] flavoprotein subunit

Small molecules or mutations can inhibit SDHA, causing succinate accumulation, impaired electron transport, and HIF stabilization, which contribute to tumorigenesis[1].