Target intelligence / Profile preview

Succinic Semialdehyde Reductase (SSAR)

Target: SSAR
Molecular classification: Enzyme, Oxidoreductase, Aldehyde Reductase, Zn-dependent alcohol dehydrogenase family

Overview

Succinic semialdehyde reductase (SSAR) is an enzyme that catalyzes the reduction of succinic semialdehyde (SSA) to γ-hydroxybutyrate (GHB), using NADPH as a cofactor. It is involved in the GABA shunt pathway and plays roles in neurotransmitter regulation, energy metabolism, and carbon fixation in some organisms. Some SSAR homologs also exhibit broader substrate specificity, including detoxification of aldehydes.

Mechanism of action

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to γ-hydroxybutyrate.

Biological functions

Reduces succinic semialdehyde to γ-hydroxybutyrateGABA metabolismNeuromodulation (via GHB production)Carbon fixation (in some prokaryotes)Detoxification (of aldehydes in some organisms)

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