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Sucrase-Isomaltase (None)

Target: None
Molecular classification: Enzyme, Glycoside Hydrolase family 31 (GH31)

Overview

Sucrase-isomaltase is a bifunctional enzyme complex located on the brush border of the small intestine, essential for carbohydrate digestion. It hydrolyzes sucrose, maltose, isomaltose, and starch-derived oligosaccharides into absorbable monosaccharides (glucose and fructose). Mutations in the SI gene can lead to Congenital Sucrase-Isomaltase Deficiency (CSID).

Mechanism of action

Hydrolyzes α-1,2, α-1,6, and α-1,4 glucosidic bonds

Biological functions

Carbohydrate digestionHydrolysis of sucroseHydrolysis of maltoseHydrolysis of isomaltoseHydrolysis of starch-derived oligosaccharides

Disease associations

Congenital Sucrase-Isomaltase Deficiency (CSID)

Safety considerations

Malabsorption symptoms (diarrhea) upon sucrose/starch ingestion in deficient individuals

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