Target intelligence / Profile preview

Sucrose transporter (SUT)

Target
SUT
Molecular classification
Transporter, Major Facilitator Superfamily (MFS), Integral membrane protein
01

Overview

Sucrose transporters are membrane-bound proteins belonging to the Major Facilitator Superfamily (MFS) and are crucial for the active transport of sucrose across plant cell membranes. They are responsible for the **allocation of sucrose**, the principal transportable carbon source in higher plants, from photosynthetic tissues (sources) to non-photosynthetic tissues (sinks)[3]. Sucrose transporters operate via a mechanism coupling proton influx and sucrose import, with conserved binding and regulatory features such as Asp152 (in the SUC1 example)[1]. Their function is vital for plant growth, productivity, and adaptation to stress, and they are regulated by protein-protein interactions and post-translational modifications[2]. Sucrose transporters have a family of isoforms present across diverse plant species, reflecting gene family expansion for specialized functions in different tissues and developmental stages[3][4]. They are not relevant targets in human therapeutics but play essential roles in agriculture and plant biotechnology.

Other names
Sucrose carrier (SUC)SUT proteinDisaccharide transporter
02

Mechanism of action

Mediates proton-coupled symport of sucrose across biological membranes. Functions through direct coupling of sucrose binding to proton binding at a conserved site (Asp152 in SUC1). Regulated by post-translational modifications and protein–protein interactions.

03

Biological functions

Allocation of carbon resources from source to sink organsSugar transport and distribution within vascular plantsSignal transduction related to sugar levels and stress responsesRegulation of starch biosynthesis and metabolic adaptation
04

Disease associations

No direct human disease roles; central in plant stress responses and possibly in agricultural science (e.g., yield, resource allocation)
05

Safety considerations

Manipulating SUT expression may disrupt plant sugar homeostasis, potentially affecting growth or stress toleranceNo safety concerns in human medical context
06

Interacting drugs

No drugs known to target sucrose transporters in human medicine (not relevant for therapeutics outside plant science)

1 more in the full profile.

07

Biomarkers

No known clinical biomarkers (mainly studied in plant system biology)SUT gene expression levels may serve as physiological markers in plants

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