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Target intelligence / Profile preview
Sudan Virus Glycoprotein (SUDV GP)
- Target
- SUDV GP
- Molecular classification
- Viral protein, Glycoprotein, Surface protein
01
Overview
The Sudan virus glycoprotein (SUDV GP) is the sole surface protein of the Sudan ebolavirus (SUDV), essential for viral entry. It mediates attachment and membrane fusion by interacting with cell-surface lectins (DC-SIGN, L-SIGN) and the endosomal receptor Niemann-Pick C1 (NPC1). Structural features include a mucin-like domain that shields epitopes and a critical disulfide bond. A polymorphism at residue 95 (Q/K) affects stability. SUDV GP is a major target for neutralizing antibodies but presents challenges due to structural variability. It is crucial for viral infectivity and species specificity.
- Other names
- Sudan ebolavirus glycoproteinSUDV Envelope Glycoprotein
02
Mechanism of action
Inhibition of viral entry
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune evasion
04
Disease associations
InfectionViral pathogenesis
05
Safety considerations
Structural variability among ebolavirusesShielding of epitopes by glycosylationPotential for escape mutants
06
Interacting drugs
Imipramine
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