Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
N-sulphoglucosamine sulphohydrolase (SGSH)
- Target
- SGSH
- Molecular classification
- Enzyme, Hydrolase
01
Overview
N-sulphoglucosamine sulphohydrolase is a lysosomal enzyme that catalyzes the removal of sulfate groups from glucosamine residues in heparan sulfate. It is essential for the degradation of glycosaminoglycans (GAGs) within lysosomes. Mutations in SGSH lead to mucopolysaccharidosis type IIIA (MPS IIIA), also known as Sanfilippo syndrome type A, a severe lysosomal storage disorder.
- Other names
- SulfamidaseHeparan N-sulfataseHeparan sulfate sulfataseHSSSFMDN-sulfoglucosamine sulfohydrolase
02
Mechanism of action
Hydrolyzes terminal N-sulfated glucosamines on heparan sulfate, removing sulfate groups.
03
Biological functions
Glycosaminoglycan catabolismLysosomal functionHeparan sulfate degradation
04
Disease associations
Mucopolysaccharidosis type IIIASanfilippo syndrome type A
05
Safety considerations
Therapeutic challenges in enzyme replacement therapy or gene therapy for MPS IIIA, including delivery to the central nervous system and potential immune responses.
Beyond the preview
Go deeper on N-sulphoglucosamine sulphohydrolase (SGSH).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on N-sulphoglucosamine sulphohydrolase (SGSH).