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Sulfatase 2 (SULF2)
- Target
- SULF2
- Molecular classification
- Enzyme, Sulfatase, Heparan sulfate 6-O-endosulfatase
01
Overview
Sulfatase-2 (SULF2) is an extracellular enzyme that removes 6-O-sulfate groups from heparan sulfate proteoglycans (HSPGs), modulating their interactions with growth factors and cytokines. It plays a role in cell signaling, cancer progression, and inflammation. High expression is associated with poor prognosis in certain cancers.
- Other names
- HSULF-2sulfatase 2
02
Mechanism of action
Inhibition of SULF2 alters heparan sulfate proteoglycan sulfation patterns, modulating growth factor and cytokine signaling.
03
Biological functions
Heparan sulfate modificationCell signaling modulationGrowth factor regulationCytokine regulationExtracellular matrix remodeling
04
Disease associations
CancerInflammationHepatocellular carcinomaGliomaHead and Neck Squamous Cell CarcinomaRheumatoid ArthritisNephrotic SyndromeInflammatory Bowel Disease
05
Safety considerations
Potential for off-target effects due to broad expression of HSPGsComplex role in multiple signaling pathways may lead to unpredictable consequences
06
Biomarkers
SULF2 mRNA expressionSULF2 protein expression
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